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doi: 10.3390/antiox13091145, 100

In a mouse model study, psychological stress-induced oxidative damage disrupted the granulocyte-lymphocyte balance, increasing granulocyte count, elevating ROS production, and raising peroxynitrite levels and lipid peroxidation in the brain, heart, liver, and spleen [223]

However, the antitumor effect of monotherapy still cannot satisfy the therapeutic needs due to the disadvantages of TME, such as severe hypoxia condition and overexpressed GSH