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38 The recent NICE guidance on Tobacco harm reduction approaches to smoking 36 advises that a tobacco harm reduction approach may be helpful for people who: May not be able to stop smoking (or do not want to stop) in one step May want to stop smoking, without necessarily giving up nicotine May not be ready to stop smoking, but want to reduce the amount they smoke

BAT is already running pre-clinical trials and says it could produce 1-3m doses per week by June (if it gets approval)

Refuting tobacco-industry funded research: empirical data shows decline in smoking prevalence following introduction of plain packaging in Australia

They are more effective for smokers with severe dependencies