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Traditional cigarettes contain over 4,000 chemicals, including at least 70 known carcinogens

To avoid randomized non-starters and potential bias due to differential early attrition from prior knowledge of group assignment, randomization will occur at the time of visit 0 when participants first receive tobacco products specific to their assigned condition, and neither the research assistant nor participant will know the assignment in advance

While human smokers develop a degree of tolerance to nicotine over time, most people would feel pretty uncomfortable and sick if they ate a cigarette, and while it is unlikely to be fatal, it would still be unpleasant

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