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However, the fetal liver is quite limited in metabolic functions: the metabolism enzymes are simply not well-developed (Jiang et al., In vivo PK profile data of drugs, such as the vasodilators for treating IUGR (Sharp and Alfirevic, in silico PK approach may be the only feasible option to estimate the nicotine and cotinine concentration in fetuses for ethical concerns

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Studies have shown that because of hormonal changes, women in the middle of menstrual cycle and the ones taking oral contraceptives (birth control pills) have a higher tendency of having alveolar osteitis after their tooth extraction surgery